Chinmay ChetanShailendra Kumar SinghSaikat PatraGirish Gupta2025-09-182024-01-02Chetan C, Singh SK, Patra S, Gupta G. Neonatal nephrotic syndrome: all is not gloomy. BMJ Case Rep. 2024 Jan 24;17(1):e255584. doi: 10.1136/bcr-2023-255584. PMID: 38272526; PMCID: PMC10826483.1757-790Xhttp://10.0.2.71/handle/123456789/264Congenital nephrotic syndrome (CNS) is a rare clinical syndrome with a constellation of proteinuria, hypoalbuminemia and oedema, presenting within 3 months of birth. We present a rare case of neonatal nephrotic syndrome with a probable sepsis induced aetiology. The neonate was referred at day of life 15 with Klebsiella pneumonia sepsis and anasarca. On investigation, the patient had nephrotic range proteinuria, hypoalbuminemia, generalized anasarca and ascites. The neonate was started on broad-spectrum antibiotics and furosemide. Genetic and other secondary causes of CNS were ruled out. With supportive management and resolution of sepsis, the neonate improved. This case highlights the rare cause of sepsis-induced nephrotic syndrome (NS), which required only supportive treatment without the need for aggressive management of CNS.eninfectious diseasesneonatal intensive carenephrotic syndromeproteinureaurinary and genital tract disordersArticle